Large Scale Custom Peptide Synthesis

Large Scale Custom Peptide Synthesis

Bio-Synthesis has been producing synthetic peptides for over 25 years. Our expertise in custom synthetic polypeptide manufacturing allows us to produce the high-quality, large-scale, and GMP peptides with the highest success rate with long standing records. We have been delivered more than 100,000 peptides to customers worldwide, including very hydrophobic polypeptide, peptide with multiple disulfide bonds, multi-phosph0rylated peptides and extremely long peptides. Our large scale non-GMP ever delivered 5 kilograms of peptides on a single order and has the capacity of 10,000 peptides per month. Our capacity of GMP peptide is 10 kilograms.


Peptide Applications

Peptide applications play an important role in biochemistry, molecular biology, immunology and medicine. In the human body, most if not all biological/physiological processes are regulated by various forms of molecular recognition. Most of these processes involve initiation or inhibition trough protein-protein interaction. As we know peptides and proteins due to the vast number of conformational possibilities are ideal to carry out such complex control functions.

Use of Synthetic Peptides

Synthetic peptides have been widely used for many purposes like: structure-function studies of polypeptides, as peptide hormones and hormone analogues, in the preparation of cross-reacting antibodies, in the design of novel enzyme and in drug discovery.

Biologically Active Peptides

The last 40 years have seen an enormous growth in the methodologies available to obtain peptide and protein molecules. Through recombinant methods, most labs can now assemble genes, subcloned into expression vectors and obtain a wide range of endogenous proteins; likewise the pioneering work of Bruce Merrifield, makes it possible to obtain large scale with multikilo amounts of a number of biologically active peptides.

Peptide Arrays

Bio-Synthesis of large numbers of extremely affordable custom peptides has never been easier ...

Bio-Synthesis has developed high throughput custom peptide synthesis to meet the growing demands for synthetic peptides in the proteomics boom. We offer parallel synthesis of small quantities of peptide libraries with the fastest and most efficient high throughput, delivering 96 different peptides, unbound, in a 96-well format. Each plate is individually tested for accuracy and can be used for epitope mapping, libraries, protein characterization and much more. This technique provides researchers the ability to order large numbers of peptides at extremely affordable prices and delivered in a short time.

A major reason for the demand of high throughput peptide synthesis has been the realization that synthetic peptides have become invaluable tools in elucidating important contiguous epitopes that are essential for functional and structural domains in proteins. In particular, the systematic screening with a series of overlapping fragments, called epitope mapping or substitution analogues, needs short peptides in large numbers although, in general, micro molar quantities are sufficient. In this regard, the value of using synthetic peptides as probes in biochemistry and pharmacology is comparable to the value of oligonucleotides in molecular biology. The systematic use of peptides, however, has been limited by the cost, time and special expertise or equipment required to provide a significant number of peptides for evaluation. Therefore, BSI over the past several years has developed synthesis platforms that are capable of the simultaneous synthesis of many peptides with FLEXIBILITY, SPEED, and HIGH THROUGHPUT at an economic price, resulting in a great value to our customers.

FEATURES:

• Quantity: 0.5-2 mgs
• Length: 8-20 aa average 75% pure
• 96 crude peptides per plate in 96-well format
• Optimized chemistries
• No cross contamination
• QC: MALDI-TOF Mass Spectrometry on all peptides
• Including: Electronic PDF files of QC data ( 2D bar code)
• Delivery: 7-10 days
  

Modifications:

• N-terminal biotinylation
• N-terminal acetylation
• Non-standard residue incorporation
• C-terminal amidation
• Disulfide bridge formation (cyclization)
  

Applications:

• Epitope mapping
• Alanine walking
• Single amino acid mutation screening
• Protein-protein interaction studies
• Kinase motif discovery
• Protease motif discovery

For More detail regarding Peptide Arrays please visit her : Peptide Arrays