SIRNA Synthesis

SIRNA Synthesis

Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, are a class of 20-25 nucleotide-long double-stranded RNA molecules that play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway where the siRNA interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g. as an antiviral mechanism or in shaping the chromatin structure of a genome; the complexity of these pathways is only now being elucidated.

siRNAs

siRNAs were first discovered by David Baulcombe's group in Norwich, England, as part of post-transcriptional gene silencing (PTGS) in plants, and published their findings in Science in a paper titled "A species of small antisense RNA in posttranscriptional gene silencing in plants". Shortly thereafter, in 2001, synthetic siRNAs were then shown to be able to induce RNAi in mammalian cells by Thomas Tuschl and colleagues in a paper published in Nature. This discovery led to a surge in interest in harnessing RNAi for biomedical research and drug development.

RNA Interference

RNA Interference Home has everything you need for your RNAi and siRNA research. You will find information here and links on RNAi protocols, an RNAi Forum, and RNAi bioinformatic software for design of RNAi and SiRNA inhibitory molecules.

For more information visit: www.biosyn.com

SIRNA Synthesis

SIRNA Synthesis

Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, are a class of 20-25 nucleotide-long double-stranded RNA molecules that play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway where the siRNA interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g. as an antiviral mechanism or in shaping the chromatin structure of a genome; the complexity of these pathways is only now being elucidated.

siRNAs

siRNAs were first discovered by David Baulcombe's group in Norwich, England, as part of post-transcriptional gene silencing (PTGS) in plants, and published their findings in Science in a paper titled "A species of small antisense RNA in posttranscriptional gene silencing in plants". Shortly thereafter, in 2001, synthetic siRNAs were then shown to be able to induce RNAi in mammalian cells by Thomas Tuschl and colleagues in a paper published in Nature. This discovery led to a surge in interest in harnessing RNAi for biomedical research and drug development.

RNA Interference

RNA Interference Home has everything you need for your RNAi and siRNA research. You will find information here and links on RNAi protocols, an RNAi Forum, and RNAi bioinformatic software for design of RNAi and SiRNA inhibitory molecules.

RNA Cell

RNA Cell

Biosynthesis can provide RNA, RNA analogs and chimeras in large quantities for your diagnostic and therapeutic research. Biosyn continues the tradition of providing researchers with the highest quality RNA Oligonucleotide synthesis, in quantities ranging from multi-mg to several grams. The quality of our product is controlled in compliance of ISO 9001/2000 and delivered with HPLC profile and MALDI-TOF characterization.

RNA Molecules

RNA molecules play critical and diverse roles in a staggering number of cellular processes. Processes of particular interest in the Department of Cell Biology include the examination of how RNA molecules fold within cells, how RNA-binding proteins recognize their RNA targets, how mRNAs are localized to discrete regions of cells and how small noncoding RNAs influence gene expression and cell function.

RNA Oligonucleotide Synthesis

Oligonucleotide synthesis is the non-biological, chemical synthesis of defined short sequences of nucleic acids. It is extremely useful in laboratory procedures covering a wide range of molecular biology applications. Automated synthesizers allow the synthesis of oligonucleotides up to 200 bases even longer.

RNA Research Analysis

Today RNA biology is becoming important in all areas of biomedical research. This is extremely useful for researchers who design molecules for RNA interference, and need to statistically test complex structure hypotheses.

For More information Visit : www.biosyn.com or call at :972-420-8505 !Now!