RNA Catalysis

RNA Catalysis

Biosyn Serving molecular diagnostic community since 1984. It provides great resource of RNA Research Analysis, RNA catalysis and RNA processing. We are providing comprehensive Custom RNA synthesis and modification such as RNA Chimeras and RNA Conjugations. From RNA probe selection to chemical synthesis. Our team of molecular biologists is dedicated in serving clients for their RNA research.

RNA Catalysis

Research leading to the discovery that RNA can act as a catalyst started in the 1970’s. Thomas Cech, at the University of Colorado at Boulder, was studying the excision of introns in a ribosomal RNA gene in Tetrahymena thermophila.

Ribonucleic Acid

DNA (deoxyribonucleic acid) makes RNA (ribonucleic acid) makes protein—has been established since the 1960s. The famous double helix of DNA is the cell's permanent storehouse of information. RNA transmits this information to the protein synthesis machinery, producing DNA-encoded protein.

RNA

A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention.

Custom DNA Synthesis

BSI offers DNA base synthesis in phosphodiester, phosphorothioate and methylphosphonate backbones. We offer an extensive selection of purifications and oligo modifications, such as linkers, spacers, dyes and modified bases. Also available:

* Custom oligonucleotide preparative and analytical services
* Long oligonucleotide synthesis for gene expression
* Antisense oligonucleotide synthesis
* Large scale ASR oligonucleotide productions

As always, every custom oligonucleotide synthesis is: All of our custom oligonucleotide products are:

Deprotected, desalted, lyophilized, Ready-2-Use
Quantitated 2x by UV spectrophotometry to provide an accurate measure of yield
QC checked by mass spectrometry
Fast delivery with high throughput capacity

Standard DNA (2' Deoxy) Oligonucleotide Synthesis

Unmodified Standard DNA Purifications


Unmodified Standard DNA Purifications Yields

Bio-Synthesis Inc, provide quality Custom RNA Synthesis Service

Custom RNA Synthesis

With over 20 years of experience in custom synthesis for the biomedical research communities, BSI has developed the expertise to deliver custom RNA synthesis with quality that meets all your RNAi, siRNA, shRNA and other RNA projects...

Features:

• Deprotected, desalted and ready to use
• Multi-scale capacities
• Purification by PAGE or RP-HPLC upon request
• QC analysis by MALDI-TOF Mass spectrometry, HPLC, PAGE analysis
• Fast delivery with high throughput capacity
  

Services

• Unmodified RNA
• Modified RNA
• Labeled Probes
• RNA Bioconjugations: RNA-Peptide, RNA-Small Molecules, RNA-solid support
  
• RNA Chimeras
  

Platform and Capacities

No matter how large your siRNA order, BSI has the capacity to synthesize high throughput and multi-scale siRNA oligos with speed and reliability.

Our RNA synthesis relies on the use of fast deprotection ribonucleoside phosphoramidites protected at the 2' position by a tert-butyldimethylsilyl (TBDMS) group and, at the 3' position, by a phosphoramidite.

The RNA synthesis and deprotection are performed using BSI's proprietary parallel synthesis and deprotection technologies. The use of the advanced technology enables us to synthesize oligos with higher coupling efficiency, faster deprotection, resulting in a faster turnaround time.