Friday, May 27, 2011

SARS Matrix Antibody


Catalog# :3529

A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. The M protein (Membrane protein, Matrix protein) is one of the major structural viral proteins. It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein and the nucleocapsid protein.

Additional Names : SARS Matrix (CT), SARS, SARS M

Source :SARS matrix antibody was raised against a synthetic peptide
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : SARS Matrix antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen : Human SARS Matrix (C-Terminus) Peptide (Cat. No. 3529P)
Application : SARS matrix antibody can be used for the detection of SARS matrix protein in ELISA. It will detect 10 ng of free peptide at 1 µg/ml.Other applications are pending.
Tested Application(s) : E
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat. No. 3529P - SARS Matrix Peptide
Long-Term Storage : SARS Matrix antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity : V
GI Number : 30173398
Accession Number : P59596
Short Description : (CT) SARS virus matrix protein
References
1. Marra MA, Jones SJ, Astell CR, et al. The Genome sequence of the SARS-associated corona virus. Science 2003;300:1399-404.
2. Rota PA, Oberste MS, Monroe SS, et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 2003;300:1394-9.
3. Navas-Nartin SR and Weiss S. Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development. J Neurovirol. 2004;10:75-85.
4. Opstelten DJ, Raamsman MJ, Wolfs K, et al. Envelope glycoprotein interactions in coronavirus assembly. J Cell Biol. 1995;131:339-49.
corresponding to amino acids at the carboxy-terminus of the SARS matrix protein.

No comments: