Catalog# :4459
SLIT and NTRK-like family 2 (Slitrk2) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk2 is expressed primarily in neurons in the ventricular layer of the brain. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk2 inhibited neurite outgrowth in cultured neurons. Deletion analysis indicated that the functional difference between Slitrk2 and Slitrk1 is within their intracellular domains. At least two isoforms of this protein are known to exist. This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
Additional Names : Slitrk2 (IN), SLIT and NTRK-like family 2
Description
Left: Western blot analysis of Slitrk2 in mouse brain tissue lysate with Slitrk2 antibody at (A) 1 and (B) 2 µg/ml.
Below:Immunohistochemistry of Slitrk2 in human brain tissue with Slitrk2 antibody at 2.5 µg/ml.
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Description
Left: Western blot analysis of Slitrk2 in mouse brain tissue lysate with Slitrk2 antibody at (A) 1 and (B) 2 µg/ml.
Below:Immunohistochemistry of Slitrk2 in human brain tissue with Slitrk2 antibody at 2.5 µg/ml.
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Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : Slitrk2 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application : Slitrk2 antibody can be used for detection of Slitrk2 by Western blot at 1 – 2 µg/ml.
Tested Application(s) : E, WB, IHC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 4459P - Slitrk2 Peptide
Long-Term Storage : Slitrk2 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1. Cat. No. 1403 - Mouse Brain Tissue Lysate
Species Reactivity : H, M, R
GI Number : 46397026
Accession Number : Q9H156
Short Description : (IN) SLIT and NTRK-like family 2
References
1. Aruga J and Mikoshiba K. Identification and characterization of Slitrk, a novel transmembrane protein family controlling neurite outgrowth. Mol. Cell Neurosci. 2003; 24:117-29.
2. Aruga J, Yokota N, and Mikoshiba K. Human SLITRK family genes: genomic organization and expression profiling in normal and brain tumor tissue. Gene 2003; 315:87-94.
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