Since 1984, Bio-Synthesis, the first company to provide commercial custom DNA synthesis services, has remained a major force in advancing biotechnology research both as leading supplier and developer of new technologies for unmodified DNA synthesis, custom DNA modifications, antisense oligos and DNA chimera. Biochemical researchers choose BSI as their major supplier for oligonucleotide synthesis because of our core values: QUALITY, SPEED and HIGH THROUGHPUT capabilities. Quality is not just a goal, it is a GUARANTEE. Every custom DNA synthesized must pass strict quality control guidelines before delivered to our customers. In addition to high quality production, speed of our custom DNA has improved to next day delivery in most cases. Through improvement from traditional chemistry to development of advanced state-of-the-art proprietary instrumentations, BSI has achieved the goal of providing the most economical, high throughput, quality custom DNA synthesis.
As always, every custom DNA synthesis is:
- Deprotected, desalted, lyophilized, Ready-2-Use
- Quantitated 2x by UV spectrophotometry to provide an accurate measure of yield
- Quality checked by MALDI-TOF mass spectrometry, purity check by HPLC and/or PAGE
- Custom preparative and analytical services (optional)
- Quality Assurance document including: yields, TM, MW, ug/OD and more...
- Fast delivery with high throughput capacity
Service:
Unmodified DNA Synthesis
We offered several scales of custom unmodified DNA synthesis at very competitive price. From small research custom DNA synthesis scale to large production of ASR and GMP DNA oligomers. We offer our client with one-stop solution for their custom DNA synthesis needs. See more...
Custom DNA Arrays/Libraries Oligo Synthesis
High-throughput custom DNA can be provided in 96 or 384 well plates. You can even request the plate type required for your system. Options for oligos in solution include equimolar concentration, forward and reverse primer in the same well, dilution in buffer or water, and equal or variable volume. Options for lyophilized oligos in plates includes equal nmole amounts or µg amount. See more...
DNA Modifications
BIO-SYNTHESIS offers thousand of custom DNA modifications to meet our clients needs. Modification such as DNA methylation, DNA base modification, backbone modification, and many others. See more...
Labeled DNA Probes
BSI's labeled DNA probes are routinely manufactured in 200 nmole or 1 umole scale. These fluorophore can be labeled at 5', 3' and internal position of an oligonucleotide. See more...
Antisense Oligos
Antisense oligos have been powerful tools to halt biological events, such as transcription, translation or splicing. At BSI, we offer hybrid synthesis of RNA-DNA with mix backbone linkages. See more...
Bridged Nucleic Acid (BNA) Sythesis
Synthesis BNA offers researchers with a powerful tool for diagnostic as well as for pharmaceutical applications such as antisense therapy, cellular delivery, drug delivery. See more...
DNA Chimera
Synthesis of chimeric DNA, chimeric DNA/RNA, chimeric DNA and peptide provides companies and researchers with a powerful tool for pharmaceutical applications. BSI offers BNA/DNA chimera synthesis at competitive prices and quick delivery. See more...
Analyte Specific Reagent (ASR oligos)
Bio-Synthesis Inc. is registered with the U.S. Food and Drug Administration as a Medical Device Class 1 manufacturer for Analyte Specific Reagent (ASR) products, which includes custom nucleic acid sequences for: in vitro diagnostic manufacturers, clinical laboratories or organizations that use the reagent to make tests for purposes other than providing diagnostic information to patients and practitioners. Note: According to 21CFR809.30 (d), Class I ASRs must be labeled as: "Analyte Specific Reagent. Analytical and performance characteristics are not established."
Bio-Synthesis's ASR products (GMP Oligos) are manufactured under good manufacturing practices (cGMP) in compliance with FDA regulations 21CFR864.4020 and 21CFR820.
Bio-Synthesis provides comprehensive custom antibody packages and immunological services, including epitope prediction, custom antibody synthesis
,carrier protein conjugation, immunization and purification, ELISA analysis, antibody labeling, and antibody microarrays. BSI offers peptide antigen design, using a proprietary Antigen Identifier TM design tool. Anti-peptide polyclonal antibody production is performed with the best titer guarantee in the industry, by implementing a proprietary SP-MaxTM adjuvant, a new family of adjuvants with improved properties, but minimal toxicity. BSI works with host animals under USDA license and holds an NIH Animal Welfare Assurance from the Office of Laboratory Animal Welfare for immunization. All procedures performed during immunization are described in our Standard Operation Procedures (SOPs) to ensure a high-quality product.
All custom polyclonal antibody projects are treated with strict confidentiality. Used animals, developed antigens remain the exclusive property of the customer.
From antigen selection to antibody purfication, BSI has optimized each step of the antibody production process to provided the best antibodies available.
We offer 8 standard custom antibody protocols (combinations of hosts and protocol timeframe) and 6 standard antibody packages (combinations of provisions, antigen and deliverables). For information about a particular protocol, see our Polyclonal Antibody Services below or request a quote today.
- Single anti-peptide polyclonal antibody
- Peptide phospho-specific polyclonal antibody
- Multiple-peptide co-immunization
- Multiple antigen peptide (MAP) polyclonal antibody
- User-supplied antigen
- Create-your-own antibody packages
Why choose Bio-Synthesis for your custom polyclonal antibody services?
Advanced antigen design- Proprietary Antigen Identifier design tool with team of expert scientist to assist client for best peptide antigen selection
- Supreme adjuvant SP-MAX technology
- A new family of adjuvants with improved properties, but minimal toxicity which ensures high specificity and titer of the produced antibodies.
- ELISA Guarantee
- Our polyclonal antibodies have an ELISA titer of 1:20,000 or better for any host if peptide antigens were designed, synthesized, and conjugated by Bio-Synthesis.
Comprehensive antibody packages
- Single anti-peptide polyclonal antibody
- Peptide phospho-specific polyclonal antibody
- Multiple-peptide co-immunization
- Multiple antigen peptide (MAP) polyclonal antibody
- User-supplied antigen
- Create-your-own antibody packages
