Custom DNA Synthesis Services

Since 1984, Bio-Synthesis, the first company to provide commercial custom DNA synthesis services, has remained a major force in advancing biotechnology research both as leading supplier and developer of new technologies for unmodified DNA synthesis, custom DNA modifications, antisense oligos and DNA chimera. Biochemical researchers choose BSI as their major supplier for oligonucleotide synthesis because of our core values: QUALITY, SPEED and HIGH THROUGHPUT capabilities. Quality is not just a goal, it is a GUARANTEE. Every custom DNA synthesized must pass strict quality control guidelines before delivered to our customers. In addition to high quality production, speed of our custom DNA has improved to next day delivery in most cases. Through improvement from traditional chemistry to development of advanced state-of-the-art proprietary instrumentations, BSI has achieved the goal of providing the most economical, high throughput, quality custom DNA synthesis.

As always, every custom DNA synthesis is:

• Deprotected, desalted, lyophilized, Ready-2-Use
• Quantitated 2x by UV spectrophotometry to provide an accurate measure of yield
• Quality checked by MALDI-TOF mass spectrometry, purity check by HPLC and/or PAGE
• Custom preparative and analytical services (optional)
• Quality Assurance document including: yields, TM, MW, ug/OD and more...
• Fast delivery with high throughput capacity

Service:
Unmodified DNA Synthesis
We offered several scales of custom unmodified DNA synthesis at very competitive price. From small research custom DNA synthesis scale to large production of ASR and GMP DNA oligomers. We offer our client with one-stop solution for their custom DNA synthesis needs. See more...

Custom DNA Arrays/Libraries Oligo Synthesis
High-throughput custom DNA can be provided in 96 or 384 well plates. You can even request the plate type required for your system. Options for oligos in solution include equimolar concentration, forward and reverse primer in the same well, dilution in buffer or water, and equal or variable volume. Options for lyophilized oligos in plates includes equal nmole amounts or µg amount. See more...

DNA Modifications
BIO-SYNTHESIS offers thousand of custom DNA modifications to meet our clients needs. Modification such as DNA methylation, DNA base modification, backbone modification, and many others. See more...

Labeled DNA Probes
BSI's labeled DNA probes are routinely manufactured in 200 nmole or 1 umole scale. These fluorophore can be labeled at 5', 3' and internal position of an oligonucleotide. See more...

Antisense Oligos
Antisense oligos have been powerful tools to halt biological events, such as transcription, translation or splicing. At BSI, we offer hybrid synthesis of RNA-DNA with mix backbone linkages. See more...

Bridged Nucleic Acid (BNA) Sythesis
Synthesis BNA offers researchers with a powerful tool for diagnostic as well as for pharmaceutical applications such as antisense therapy, cellular delivery, drug delivery. See more...

DNA Chimera
Synthesis of chimeric DNA, chimeric DNA/RNA, chimeric DNA and peptide provides companies and researchers with a powerful tool for pharmaceutical applications. BSI offers BNA/DNA chimera synthesis at competitive prices and quick delivery. See more...

Analyte Specific Reagent (ASR oligos)
Bio-Synthesis Inc. is registered with the U.S. Food and Drug Administration as a Medical Device Class 1 manufacturer for Analyte Specific Reagent (ASR) products, which includes custom nucleic acid sequences for: in vitro diagnostic manufacturers, clinical laboratories or organizations that use the reagent to make tests for purposes other than providing diagnostic information to patients and practitioners. Note: According to 21CFR809.30 (d), Class I ASRs must be labeled as: "Analyte Specific Reagent. Analytical and performance characteristics are not established."

Bio-Synthesis's ASR products (GMP Oligos) are manufactured under good manufacturing practices (cGMP) in compliance with FDA regulations 21CFR864.4020 and 21CFR820.