Catalog# :4417
Plxdc2, also known as Tumor endothelial marker 7-related (TEM7R) encodes a protein with 57% amino acid identity to TEM7, the most abundant tumor endothelial marker. Plxdc2 is strongly expressed in the endothelial cells of the tumor stroma, but not in the endothelial cells of normal colonic tissue. Plxdc2 is also expressed at high levels in vessels of some normal tissues, with highest expression in muscle and lung. Plxdc2 and TEM7 may be important for tumor angiogenesis in humans. Cortactin was identified as a protein capable of binding to the extracellular region of both TEM7 and Plxdc2, and may provide new opportunities for the delivery of therapeutic and imaging agents to the vessels of solid tumors.
Additional Names : Plxdc2 (NT), Plexin domain-containing protein 2, Tumor endothelial marker 7-related protein, TEM7R
DescriptionLeft: Western blot analysis of Plxdc2 in human brain tissue lysate with Plxdc2 antibody at (A) 0.5 (B) 1 µg/ml.
Below: Immunohistochemical staining of human brain tissue using Plxdc2 antibody at 2.5 µg/ml.
Other Product Images
Source :Plxdc2 antibody was raised against a 18 amino acid peptide from near the amino terminus of human Plxdc2.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : Plxdc2 antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.
Application : Plxdc2 antibody can be used for detection of Plxdc2 by Western blot at 0.5 – 1 µg/ml.
Tested Application(s) : E, WB, IHC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 4417P - Plxdc2 Peptide
Long-Term Storage : Plxdc2 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1. Cat. No. 1303 - Human Brain Tissue Lysate
Species Reactivity : H, M, R
GI Number : 74749416
Accession Number : Q6UX71
Short Description : (NT) TEM7 receptor
References
1. Carson-Weber EB, Watkins DN, Nanda A, et al. Cell surface tumor epithelial markers are conserved in mice and humans. Cancer Res. 2001; 61:6649-55.
2. Nabda A and St. Croix Bl. Tumor endothelial markers: new targets for cancer therapy. Curr Opin Oncol. 2004; 16:44-9.
3. St. Croix B, Rago C, Velculescu V, et al. Genes expressed in human tumor endothelium. Science 2000; 289:1197-202.
4. Nanda A, Buckhaults P, Seaman S, et al. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. Cancer Res. 2004; 64:8507-11.
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