CDIP Antibody

CDIP Antibody

Catalog# : 5059

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.

Additional Names : CDIP (IN2), Cell death involved p53-target
Description
Left: Western blot analysis of CDIP in human brain lysate with CDIP antibody at (A) 0.25 and (B) 0.5 µg/ml.






Source : CDIP antibody was raised against a 19 amino acid peptide near the center of human CDIP.

Purification : Affinity chromatography purified via peptide column

Clonality and Clone : This is a polyclonal antibody.

Host : CDIP antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.

Application : CDIP antibody can be used for detection of CDIP by Western blot at 0.25 – 0.5 µg/ml.

Tested Application(s) : E, WB

Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.

Blocking Peptide : Cat.No. 5059P - CDIP Peptide

Long-Term Storage : CDIP antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Positive Control
1.Cat. No. 1303 - Human Brain Tissue Lysate

Species Reactivity :H, M

GI Number : 118344450

Accession Number : NP_037531

Short Description : (IN2) Cell death involved p53-target

References

1.Guimaraes DP and Hainaut P. TP53: a key gene in human cancer. Biochimie 2002; 84:83-93.
2.Brown L, Ongusaha PP, Kim H-H, et al. CDIP, a novel pro-apoptotic gene, regulates TNFa-mediated apoptosis in a p53-dependent manner. EMBO J. 2007; 26:3410-22.