Catalog# : PM-4821
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim is another BH3 domain containing protein which can induce apoptosis. Bim interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.
Additional Names : Bim (1C2H4): Bcl-2 interacting protein, Bcl-2-related ovarian death gene, BOD, Bcl-2-like 11
DescriptionLeft: Western blot analysis of 5 ng of Bim recombinant protein with Bim antibody at 1 µg/ml. Below: Immunocytochemistry of Bim in K562 cells with Bim antibody at 10 µg/ml.
Source :Mouse monoclonal Bim antibody was raised against a recombinant protein corresponding to amino acids 2 to 198 of human Bim.
Purification : Immunoaffinity chromotography purified IgG
Clonality and Clone : This is a monoclonal antibody. (Clone 1C2H4)
Host : Bim monoclonal antibody was raised in mouse.
Immunogen : Mouse monoclonal Bim antibody was raised against a recombinant protein corresponding to amino acids 2 to 198 of human Bim.
Tested Application(s) : E, WB, ICC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Long-Term Storage : Bim monoclonal antibody can be stored at 4ºC, stable for one year.
Positive Control
- Cat. No. 95-107 - Bim Recombinant Protein
Short Description : A Bcl-2 interacting protein
References
- O'Connor L, Strasser A, O'Reilly LA, et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998; 17:384-395.
- Hsu SY, Lin P, and Hsueh AJ BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol. Endocrinol. 1998; 12:1432-40.
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