Catalog# :4569
Retrograde golgi transport homolog 1 (RGP1) is the mammalian homolog to the yeast RGP1, a protein that forms a tight complex with RIC1. This complex binds Ypt6p and stimulates guanine nucleotide exchange. RGP1 is localized to the Golgi and is thought to be a potential Golgi recycling factor. Rgp1 yeast mutants exhibit defects in retrograde trafficking similar to those seen in yeast with mutations in other retrograde Golgi transport proteins. It is expected that RGP1 plays a similar role in mammalian cells to that seen in yeast.
Additional Names : RGP1 (NT), Retrograde golgi transport homolog1
Description
Left: Western blot analysis of RGP1 in human heart tissue lysate with RGP1 antibody at (A) 1 and (B) 2 µg/ml.
Source :RGP1 antibody was raised against a 17 amino acid peptide near the amino terminus of the human RGP1.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : RGP1 antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.
Application : RGP1 antibody can be used for detection of RGP1 by Western blot at 1 – 2 µg/ml.
Tested Application(s) : E, WB
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 4569P - RGP1 Peptide
Long-Term Storage : RGP1 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1. Cat. No. 1301 - Human Heart Tissue Lysate
Species Reactivity : H, M, R
GI Number : 122937426
Accession Number : NP_001073965
Short Description : (IN) Retrograde golgi transport homolog1
References
1. Siniossoglou S, Peak-Chew SY, and Pelham HRB. Ric1p and Rgp1 form a complex that catalyzes nucleotide exchange on Ypt6p. EMBO J. 2000; 19:4885-94.
2. Panek HR, Conibear E, Bryan JD, et al. Identification of Rgp1, a novel Golgi recycling factor, as a protein required for efficient localization of yeast casein kinase 1 to the plasma membrane. J. Cell Sci. 113:4545-55.
No comments:
Post a Comment