Catalog# :4587
The RANBP2-like and GRIP domain containing 5 protein (RGPD5) has high similarity to RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. The gene coding for RGPD5 is thought to have arisen from a gene duplication event of RANBP2 as these highly homologous genes are located close to each other at chromosome 2q11-q12. RGPD5 was identified as an HIV dependency factor (HDF), suggesting that RGPD5 may be an important drug target in HIV treatment. At least two isoforms of RGPD5 are known to exist, of which the shorter isoform is expressed primarily in testis, while the longer of the two is expressed at low levels in a number of somatic tissues.
Additional Names : RGPD5 (IN), RANBP2-like and GRIP domain-containing protein 5, RGP5, RANBP2L1
DescriptionLeft: Western blot analysis of RGPD5 in human thymus tissue lysate with RGPD5 antibody at 1 µg/ml in (A) the absence and (B) the presense of blocking peptide.
Source :RGPD5 antibody was raised against a 23 amino acid peptide from near the center of human RGPD5.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : RGPD5 antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.
Application : RGPD5 antibody can be used for detection of RGPD5 by Western blot at 1 – 2 µg/ml.
Tested Application(s) : E, WB
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 4587P - RGPD5 Peptide
Long-Term Storage : RGPD5 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1. Cat. No. 1314 - Human Thymus Tissue Lysate
Species Reactivity : H
GI Number : 83267877
Accession Number : NP_005045
Short Description : RANBP2-like and GRIP domain-containing protein 5
References
1. Nothwang HG, Rensing C, Kubler M, et al. Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on chromosome 2q11-q12. Genomics 1998; 47:383-92.
2. Brass AL, Dykxhoorn DM, Benita Y, et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science 2008; 319:921-6.
3. Wang LF, Zhu HD, Miao SY, et al. Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene. Arch. Androl. 1999; 42:71-84.
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