Catalog# :5259
Scavenger receptor class A member 5 (SCARA5), also known as TESR, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARA5 is a cell-surface receptor that contains that collagen-like domain and N-terminal scavenger receptor cysteine rich domain typical of the class A scavenger receptor subfamily. Unlike other class A receptors, SCARA5 does not endocytose acetylated or oxidized low density lipoprotein. Instead, SCARA5 binds serum ferritin and mediates its endocytosis from the cell surface, indicating SCARA5 may play a role in non-transferrin iron delivery. At least four isoforms of SCARB1 are known to exist.
Additional Names : SCARA5, Scavenger receptor class A member 5, TESR
DescriptionLeft: Western blot analysis of SCARA5 in human liver tissue lysate with SCARA5 antibody at 1 µg/ml.
Below: Immunocytochemistry of SCARA5 in HepG2 cells with SCARA5 antibody at 2.5 μg/ml.
Other Product Images
Source :SCARA5 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human SCARA5.Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : SCARA5 antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.
Application : SCARA5 antibody can be used for detection of SCARA5 by Western blot at 1 - 2 µg/ml.
Tested Application(s) : E, WB
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 5259P - SCARA5 Peptide
Long-Term Storage : SCARA5 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1. Cat. No. 1306 - Human Spleen Tissue Lysate
Species Reactivity : H, M
GI Number : 47271477
Accession Number : NP_776194
Short Description : Scavenger receptor class A member 5
References
1. Greaves DR, Gough PJ, and Gordon S. Recent progress in defining the role of scavenger receptors in lipid transport, atherosclerosis and host defence. Curr. Op. Lipid. 1998; 9:425-32.
2. Jiang Y, Oliver P, Davies KE, et al. Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells. J. Biol. Chem. 2006; 281:11834-45.
3. Li JY, Paragas N, Ned RM, et al. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev. Cell 2009; 16:35-46.
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