Catalog# :5115
Matrilin (MATNs) are a family of non-collagenous extracellular matrix proteins consisting of four known members that have been proposed to play key roles in the formation of both collagen-dependent and collagen-independent filamentous networks. Members of the matrilin family all share a structure made up of von Willebrand factor A domains, epidermal growth factor-like domains and a coiled coil α-helical module. MATN1 and MATN3 are expressed mainly in cartilage, while MATN2 and MATN4 occur in a wide variety of extracellular matrices such as embryonic kidney, lung, bone, cartilage and nervous system. The matrilin genes are strictly and differently regulated and their expression may serve as markers for cellular differentiation. MATN4 could serve as an odontoblast differentiation marker, e.g. in odontoblast stem cell research.
Additional Names : MATN4, Matrilin 4
DescriptionLeft: Western blot analysis of MATN4 in rat brain tissue lysate with MATN4 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
Below: Immunohistochemistry of MATN4 in mouse brain tissue with MATN4 antibody at 2.5 µg/ml.
Other Product Images
Source :MATN4 antibody was raised against a 13 amino acid peptide near the amino terminus of human MATN4.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : MATN4 antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.
Application : MATN4 antibody can be used for detection of MATN4 by Western blot at 1 - 2 µg/ml.
Tested Application(s) : E, WB, IHC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 5115P - MATN4 Peptide
Long-Term Storage : MATN4 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1. Cat. No. 1463 - Rat Brain Tissue Lysate
Species Reactivity : H, M, R
GI Number : 13699834
Accession Number : NP_085080
Short Description : Matrilin 4
References
1. Pei M, Luo J, and Chen Q. Enhancing and maintaining chondrogenesis of synovial fibroblasts by cartilage extracellular matrix protein matrilins. Osteoarthritis Cartilage 2008; 16:1110-7.
2. Frank S, Schulthess T, Landwehr R, et al. Characterization of the Matrilin Coiled-coil Domains Reveals Seven Novel Isoforms. J. Biol. Chem. 2002; 277:19071-9.
3. Deak F, Wagener R, Kiss I, et al. The matrilins: a novel family of oligomeric extracellular matrix proteins. Matrix Biol. 1999; 18:55-64.
4. Klatt AR, Nitche DP, Kobbe B, et al. Molecular structure, processing, and tissue distribution of matrilin. J. Biol. Chem. 2001; 276:17267-75.
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