Catalog# :4235
Op18 belongs to the stathmin family of genes and encodes a ubiquitous cytosolic phosphoprotein that may function as an intracellular relay integrating several signaling pathways such as those involved in cell proliferation and differentiation. Op18 has also been shown to be involved in the regulation of the microtubule filament system by destabilizing microtubules, thereby preventing assembly and promoting the disassembly of microtubules. More recently, op18 has been implicated as a potential target of the ASK1-p38 MAP kinase cascade, suggesting that the ASK1-p38 cascade may regulate microtubule dynamics through op18. Op18 is highly expressed in a wide variety of human malignancies, including leukemia, prostate cancer, ovarian carcinoma, and breast carcinoma, suggesting that op18 may be an ideal target for anti-cancer therapeutics.
Additional Names : op18 (CT), oncoprotein 18, STMN1, Stathmin 1, Lag, LAP18
DescriptionLeft: Western blot analysis of op18 in EL4 cell lysate with op18 antibody at (A) 0.5, (B) 1 and (C) 2 µg/ml.
Below: Immunohistochemistry of op18 in human brain tissue with op18 antibody at 2.5 µg/ml.
Other Product Images
Source : Op18 antibody was raised against a 20 amino acid peptide from near the carboxy terminus of human op18.Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : op18 antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.
Application : Op18 antibody can be used for detection of op18 by Western blot at 0.5 – 1 µg/ml.
Tested Application(s) : E, WB, IHC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 4235P - op18 Peptide
Long-Term Storage : op18 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1.Cat. No. 1287 - EL4 Lysate
2.Cat. No. 1303 - Human Brain Tissue Lysate
Species Reactivity : H, M
GI Number : 51895905
Accession Number : AAH82228
Short Description : (CT) a member of the Stahmin family of proteins
References
1. Curmi PA, Gavet O, Charbaut E, et al. Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin. Cell Structure and Function 1999; 24:345-57.
2. Belmont LD and Mitchison TJ. Identification of a protein that interacts with tubulin dimers and increases catastrophe rate of microtubules. Cell 1996; 84:623-31.
3. Mizumura K, Takeda K, Hashimoto S, et al. Identification of op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade. J. Cell Physiol. 2006; 206:363-70.
4. Mistry SJ and Atweh GF. Role of stathmin in the regulation of the mitotic spindle. Mount Sinai J. Med. 2002; 69:299-304.
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