Catalog# :4881
MettL7B belongs to the methyltransferase superfamily. It is a probable methyltransferase. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Often methylation occurs on nucleic bases in DNA or amino acids in protein structures. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. DNA methylation may be necessary for normal growth from embryonic stages in mammals. When mutant embryonic stem cells lacking the murine DNA methyltransferase gene were introduced to a germline of mice they caused a recessive lethal phenotype. Methylation may also be linked to cancer development as methylation of tumor suppressor genes promotes tumorgenesis and metastasis. This MettL7B antibody is predicted to not cross-react with MettL7A.
Additional Names : MettL7B (CT), Methyltransferase-like protein 7B
DescriptionLeft: Western blot analysis of MettL7B in rat spleen tissue lysate with MettL7B antibody at (A) 2 and (B) 4 µg/ml.
Below: Immunohistochemistry of Mett7LB in human spleen tissue with MettL7B antibody at 2.5 µg/ml.
Other Product Images
Source :MettL7B antibody was raised against a 16 amino acid peptide near the carboxy terminus of human MettL7B.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : MettL7B antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.
Application : MettL7B antibody can be used for detection of Mettl7B by Western blot at 2 – 4 µg/ml.
Tested Application(s) : E, WB, IHC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 4881P - MettL7B Peptide
Long-Term Storage : MettL7B antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1. Cat. No. 1466 - Rat Spleen Tissue Lysate
Species Reactivity : H, M, R
GI Number : 164663805
Accession Number : NP_689850
Short Description : (CT) Methyltransferase-like protein 7B
References
1. Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003; 13:2265-70.
2. Li E, Bestor TH, and Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992; 69:915-26.
3. Laird PW and Jaenisch R. DNA Methylation and Cancer. Human Molecular Genetics 1994; 3:1487-95.
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