Aven Antibody

Aven Antibody

Catalog# : 2417

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE.

Additional Names : Aven (NT), Apoptosis caspase activation inhibitor

Description
Left: Western blot analysis of Aven in Raji cell lysate with Aven antibody at 1 µg/ml in (A) the presence and (B) the absence of blocking peptide. Below: Immunohistochemistry of Aven in human spleen tissue with Aven antibody at 5 µg/ml.

Source :Aven antibody was raised against a 18 amino acid peptide from near the amino terminus of human Aven.

Purification : Affinity chromatography purified via peptide column

Clonality and Clone : This is a polyclonal antibody.

Host : Aven antibody was raised in rabbit.

Tested Application(s) : E, WB, IHC

Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.

Blocking Peptide : Cat.No. 2417P - Aven Peptide

Long-Term Storage : Aven antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Positive Control

• Cat. No. 1207 - Raji Cell Lysate
• Cat. No. 1306 - Human Spleen Tissue Lysate
  

Species Reactivity :H, M, R

GI Number : 9966841

Accession Number : NP_065104

Short Description : (NT) a Bcl-xL-interacting protein

References

1. Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
2. Chau BN, Cheng EH-Y, Kerr DA, et al. Aven, a novel inhibitor of caspase activation. Binds Bcl-xL and Apaf-1. Mol. Cell 2000; 6:31-40.
3. Paydas S, Tanriverdi K, Yavuz S, et al. Survivin and aven: two distinct antiapoptotic signals in acute leukemias. Ann. Oncology 2003; 14:1045-50.

For more detail regarding Peptides please visit here : Custom Peptide Synthesis