Bio-Synthesis offer custom construction of polymer bioconjugation by covalently attached synthetic PEG (polyethylene glycol) polymer to nucleic acids, peptides, enzymes, carbohydrates. These polymer bioconjugates, sometimes called "bio-hybrid" or "macromolecular chimeras" have many benefits. Benefits range beyond biomedical field and includes issues as diverse as bio-sensors, artificial enzymes, biometrics, and much more.
PEG (Polyethylene glycol) Polymer
PEG (polyethylene glyco), the most often used polymer. This chemical compound composed of repeating ethylene glycol units. It also known as poly ethylene oxide (PEO) and polyoxyethylene (POE) with molecular weights from 300g/mol to 10,000,000 g/mol.
The attachment of a PEG polymer to a therapeutic molecule called PEGylation. This technology is now widely used for the modification of proteins, peptides, antibody fragments, oligonucleotides and the like for use as drugs. There are advantages like: Increase bioavailability, Reduce toxicity an immunogenicity, Hydrophilic (aqueous-soluble), Highly flexible etc.
Type of PEG for Conjugation
There are various type of PEG like: Linear Activated PEGs, Multi-arm PEG conjugation, Branched PEG conjugation, Heterofuntional PEGs conjugation, Comb-Shaped Copolymers, PEG containing Biotin.