Friday, October 1, 2010

BCMA Antibody

BCMA Antibody

Catalog# : 2397

Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 (1-4) and April/TALL-2, respectively, (3,5). BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion (1,2). April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified (6,7). BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
Additional Names : BCMA
Left: Western blot analysis of BCMA in human spleen (A) tissue lysate, K562 (B), and U937 (C) cell lysates with BCMA antibody at 5 µg/ml.

Below: Immunohistochemistry of BCMA in human spleen cells with BCMA antibody at 10 µg/ml.

Other Product Images
Source : BCMA antibody was raised against a synthetic peptide mapping at the carboxy terminus of human BCMA .
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : BCMA antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.
Immunogen : Human BCMA Peptide (Cat. No. 2397P)
Application : BCMA antibody can be used for detection of BCMA by Western blot at 2 to 5 µg/ml.
Tested Application(s) : E, WB, IHC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide : Cat. No. 2397P - BCMA Peptide
Long-Term Storage : BCMA antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
1. Cat. No. 1204 - K562 Cell Lysate
2. Cat. No. 1215 - U937 Whole Cell Lysate
3. Cat. No. 1306 - Human Spleen Tissue Lysate
Species Reactivity :H
GI Number : 23238192
Accession Number : NP_001183
Short Description : Receptor for BAFF and APRIL
1. Moore PA, Belvedere O, Orr A, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285:260-3
2. Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999;189:1747-56
3. Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol 1999;65:680-3
4. Mukhopadhyay A, Ni J, Zhai Y, Yu GL, Aggarwal BB. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase. J Biol Chem 1999 ;274:15978-81

1 comment:

pSIVA said...

Hey guys,

BCMA Antibody that recognize the B Cell maturation antigen and that bind natve B cells, plasma cells, and memory B cells. This is the perfect blog for anyone who wants to know about this topic...