DNA Label

DNA Label

Bio-Synthesis, founded in 1984, is an international provider of genomic services established around the core business lines oligonucleotide and gene synthesis. Base, ribose and backbone modifications and reporter groups like dyes and haptens are routinely incorporated in DNA, RNA, LNA, and BNA. Through innovative production process and synthesis know-how, our services are the best in their class, providing you with innovative and trustworthy solutions to accelerate your research.

DNA Binding Proteins
Structural proteins that bind DNA are well-understood examples of non-specific DNA-protein interactions. Within chromosomes, DNA is held in complexes with structural proteins. These proteins organize the DNA into a compact structure called chromatin. In eukaryotes this structure involves DNA binding to a complex of small basic proteins called his tones, while in prokaryotes multiple types of proteins are involved.

DNA Modifying Enzymes
Nucleases are enzymes that cut DNA strands by catalyzing the hydrolysis of the phosphodiester bonds. Nucleases that hydrolyse nucleotides from the ends of DNA strands are called exonucleases, while endonucleases cut within strands.

Topoisomerases and Helicases
Topoisomerases are enzymes with both nuclease and ligase activity. These proteins change the amount of super coiling in DNA. Some of this enzyme work by cutting the DNA helix and allowing one section to rotate, thereby reducing its level of super coiling; the enzyme then seals the DNA break.