DNA RNA Sequence

DNA RNA Sequence

Bio-Synthesis, founded in 1984, is an international provider of genomic services established around the core business lines oligonucleotide and gene synthesis. Base, ribose and backbone modifications and reporter groups like dyes and haptens are routinely incorporated in DNA/RNA hybrid synthesis. Through innovative production process and synthesis know-how, our services are the best in their class, providing you with innovative and trustworthy solutions to accelerate your research.

DNA Synthesis

When DNA is synthesized the free 3´ hydroxyl (OH) group from the growing strand of DNA attacks the phosphate on the next base to be added (see the red arrows below). Pyrophosphate is released and the new base forms a phosphodiester bond with the growing strand of DNA. The free 3´ hydroxyl group is then free to attack the next base to be added. This reaction is catalyzed by DNA polymerases.

RNA Synthesis

RNA synthesis is said to proceed in the 5′ to 3′ direction, reflecting the fact that the attachment of new nucleotides always occurs at the 3′ hydroxyl group of the growing RNA chain. RNA synthesis goes through phases that are typical of polymerization processes: initiation, elongation, and termination, yielding an RNA product of defined size and sequence.

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