GRTP1 Antibody

GRTP1 Antibody

Catalog# : 4589

Growth hormone regulated TBC protein 1 (GRTP1) was identified through microarray analysis as a gene whose expression is regulated by growth hormone (GH). It contains the TBC signature motif of GTPase activator proteins of Rab-like small GTPases. GRTP1 mRNA is expressed at highest levels in testes, and is also present in kidney, lung, liver, and intestine. Administration of GH to mice resulted in an increase in GRTP1 mRNA in testes, but a decrease of GRTP1 mRNA in kidney and liver. GRTP1 was identified as an HIV dependency factor (HDF), suggesting that GRTP1 may be an important drug target in HIV treatment. At least three isoforms of GRTP1 are known to exist; this antibody should recognize all isoforms.
Additional Names : GRTP1 (NT), Growth hormone regulated TBC protein 1, TBC1 domain family member 6
[Image]Description
Left: Western blot analysis of GRTP1 in K562 cell lysate with GRTP1 antibody at (A) 1 and (B) 2 µg/ml.

Below: Immunocytochemistry of GRTP1 in K562 cells with GRTP1 antibody at 2.5 µg/ml.

[Image]Source : GRTP1 antibody was raised against a 18 amino acid peptide from near the amino terminus of human GRTP1.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : GRTP1 antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.
Application : GRTP1 antibody can be used for detection of GRTP1 by Western blot at 1 – 2 µg/ml.
Tested Application(s) : E, WB, ICC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide : Cat.No. 4589P - GRTP1 Peptide
Long-Term Storage : GRTP1 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
1. Cat. No. 1204 - K562 Cell Lysate
Species Reactivity :H, M, R
GI Number : 119629611
Accession Number : EAX09206
Short Description : (NT) Growth hormone regulated TBC protein 1
References
1. Lu C, Kasik J, Stephan DA, et al. Grtp1, a novel gene regulated by growth hormone. Endocriniology 2001; 142:4568-71.
2. Brass AL, Dykxhoorn DM, Benita Y, et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science 2008; 319:921-6.