MATN2 Antibody

MATN2 Antibody

Catalog# :5105

Matrilin (MATNs) are a family of non-collagenous extracellular matrix proteins consisting of four known members that have been proposed to play key roles in the formation of both collagen-dependent and collagen-independent filamentous networks. The matrilin family all share a structure made up of von Willebrand factor A domains, epidermal growth factor-like domains and a coiled coil alpha-helical module. MATN1 and MATN3 are expressed mainly in cartilage, while MATN2 and MATN4 occur in a wide variety of extracellular matrices. The matrilin genes are strictly and differently regulated and their expression may serve as markers for cellular differentiation and diseases such as astrocytoma and liver carcinoma. Recent studies show that MATN2 is a permissive substrate for axonal growth and cell migration, and it is required for successful nerve regeneration.

Additional Names : MATN2, Matrilin 2


Description
Left: Western blot analysis of MATN2 in human liver tissue lysate with MATN2 antibody at (A) 1 and (B) 2 µg/ml.











Source :
MATN2 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human MATN2.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : MATN2 antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.
Application : MATN2 antibody can be used for detection of MATN2 by Western blot at 1 - 2 µg/ml.
Tested Application(s) : E, WB
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 5105P - MATN2 Peptide
Long-Term Storage : MATN2 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1. Cat. No. 1304 - Human Liver Tissue Lysate
Species Reactivity : H, M, R
GI Number : 62548862
Accession Number : NP_085072
Short Description : Matrilin 2
References

1. Pei M, Luo J, and Chen Q. Enhancing and maintaining chondrogenesis of synovial fibroblasts by cartilage extracellular matrix protein matrilins. Osteoarthritis Cartilage 2008; 16:1110-7.
2. Frank S, Schulthess T, Landwehr R, et al. Characterization of the Matrilin Coiled-coil Domains Reveals Seven Novel Isoforms. J. Biol. Chem. 2002; 277:19071-9.
3. Deak F, Wagener R, Kiss I, et al. The matrilins: a novel family of oligomeric extracellular matrix proteins. Matrix Biol. 1999; 18:55-64.
4. Szabo E, Korpos E, Batmunkh E, et al. Expression of matrilin-2 in liver cirrhosis and hepatocellular carcinoma. Pathol. Oncol. Res. 2008; 14:15-22.