MTCH2 Antibody

MTCH2 Antibody

Catalog# : 5063

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. MTCH2 is a member of the mitochondrial carrier protein family that catalyze the exchange of substrates across the inner mitochondrial membrane and is targeted by Bid, a pro-apoptotic Bcl-2 family member, in response to apoptotic signals, suggesting that MTCH2 may play a key role in the mitochondrial apoptosis pathway.

Additional Names : MTCH2, Mitochondrial carrier homolog 2
Description
Left: Western blot analysis of MTCH2 in 293 cell lysate with MTCH2 antibody at 1 µg/ml.

Below: Immunohistochemistry of MTCH2 in mouse kidney tissue with MTCH2 antibody at 5 µg/ml.

Other Product Images

Source : MTCH2 antibody was raised against a 15 amino acid peptide near the amino terminus of human MTCH2.

Purification : Affinity chromatography purified via peptide column

Clonality and Clone : This is a polyclonal antibody.

Host : MTCH2 antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.

Application : MTCH2 antibody can be used for detection of MTCH2 by Western blot at 1 – 2 µg/ml.

Tested Application(s) : E, WB, IHC

Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.

Blocking Peptide : Cat.No. 5063P - MTCH2 Peptide

Long-Term Storage : MTCH2 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Positive Control
1. Cat. No. 1210 - 293 Cell Lysate

Species Reactivity :H

GI Number : 5815347

Accession Number : AAD52647

Short Description : Mitochondrial carrier homolog 2

References
1. Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
2. Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.
3. Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron. 2004; 39:1125-35.
4. Grinberg M, Schwarz M, Zaltsman Y, et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol. Cell. Biol. 2005; 25:4579-90.