Bioconjugates of Nucleic Acids

The availability of synthetic nucleic acids/oligonucleotides and peptides, areas where Bio Synthesis has extensive experience, has promoted the development of conjugates of these molecules cross-linked to compounds such as lipids, carbohydrates and small molecules (drugs) to yield products with distinct properties. Bio Synthesis has developed several approaches for the production of different bioconjugates. From the point of view of therapeutic applications, because of their potential uses in genetic therapy and blocking gene expression, the bioconjugates of nucleic acids are the most important ones. In general these bioconjugates acquire new properties, such as resistance to degradation and passage of the hydrophilic and anionic oligonucleotide across the hydrophobic negatively charged cell membrane or transduction. Yet, a suitable bioconjugate should maintain practically all of the oligonucleotide's biological properties.

Conjugation Services:

• Oligonucleotide Peptide or protein conjugation
• Fluorescent labeling of peptide, proteins, drugs, DNA probes, etc.
• Protein-Protein conjugation
• Antibody conjugation
• Drug-Protein, peptide oliognucleotide conjugation
• Coupling of small molecules to carrier proteins
• Coupling of small molecules or proteins to solid support
• Chemical synthesis and modification of small molecules, proteins and drugs

Our team of experienced chemists is available to help our client arrive with the design and cross-linking strategies for the best approach to develop the optimal bioconjugates. As always, every custom project undergoes strict quality control - quality is always guaranteed! Quotations and Ordering: For quotations, you may also contact us by email , toll free (1.800.227.0627), oversea (972.420.8505), fax (1-972-420-0442), or via our secure online order/quote system.