Tuesday, February 15, 2011

Constrained Nucleotide Nucleotide

Bio-Synthesis, founded in 1984, is an international provider of genomic provider established around the core business lines Oligonucleotide synthesis. Our expertise in nucleic acid chemistry has enabled us to provide our clients with extensive selection of modifications such as bases, backbone, hybrid DNA Constrained Nucleotide oligo synthesis with various scales from research discovery to multi-gram ASR/GMP production.

Constrained Nucleotide Nucleotide

Nucleotides are organic compounds that consist of three joined structures: a nitrogenous base, a sugar, and a phosphate group. The most common nucleotides can be divided into two groups (purines and pyrimidines) based on the structure of the nitrogenous base. The joined sugar is either ribose or deoxyribose. Nucleotides are the structural units of RNA and DNA. They also serve as important cofactors in cellular signaling and metabolism.

Custom Constrained Nucleotide

Custom Constrained Nucleotide (Constrained Nucleotide) was first described by Wengel and co-workers in 1981 as a novel class of conformationally restricted oligonucleotide analogues. Constrained Nucleotide is a bicyclic nucleic acid where a ribonucleoside is linked between the 2'-oxygen and the 4'-carbon atoms via a methylene unit.

Custom Constrained Nucleotide Synthesis and Purifications

BSI offer Constrained Nucleotide oligos synthesis with different versatilities. Constrained Nucleotide oligo can be order with a mixture of DNA, RNA, nucleic acid analogues and different synthesis backbone and modifications.

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