The six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP4), STEAP3 promotes both iron and copper reduction. STEAP3 is highly expressed in hematopoietic tissues and colocalizes with the transferrin endosome. Overexpression of STEAP3 stimulates iron reduction; mice lacking STEAP3 are deficient in erythroid ferrireductase activity, suggesting that STEAP3 is an endosomal ferrireductase required for transferrin-dependent iron uptake in erythroid cells. This STEAP3 antibody does not cross-react with other STEAP proteins.
Additional Names : STEAP3, Six transmembrane epithelial antigen of prostate 3, dudulin-2
Left: Western blot analysis of STEAP3 in rat liver tissue lysate with STEAP3 antibody at (A) 1 and (B) 2 µg/ml.
Below: Immunohistochemistry of STEAP3 in mouse liver tissue with STEAP3 antibody at 2.5 µg/ml.
Other Product Images
Source :STEAP3 antibody was raised against a 15 amino acid peptide from near the amino terminus of human STEAP3.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : STEAP3 antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.
Application : STEAP3 antibody can be used for detection of STEAP3 by Western blot at 1 – 2 µg/ml.
Tested Application(s) : E, WB, IHC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 4311P - STEAP3 Peptide
Long-Term Storage : STEAP3 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1. Cat. No. 1464 - Rat Liver Tissue Lysate
Species Reactivity : H, M, R
GI Number : 127801437
Accession Number : AAH95421
Short Description : Six transmembrane epithelial antigen of prostate 3
1. Ohgami RS, Campagna DR, Greer EL, et al. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat. Genet. 2005; 37:1264-9.
2. Ohgami RS, Campagna DR, McDonald A, et al. The Steap proteins are metalloreductases. Blood 2006; 108:1388-94.
3. Graham RM, Chua ACG, Herbison CE, et al. Liver iron transport. World J. Gastroenterol. 2007; 13:4725-36.