ARC Antibody

ARC Antibody

Catalog# : 2081

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1).

Additional Names : ARC (CT), ARC
Description
Left: Western blot analysis of ARC in HeLa (H), KB (K), and A549 (A) whole cell lysates with ARC antibody at 1:1000 dilution. 1st Below: Immunohistochemistry of ARC in human heart tissue at 5 µg/ml. 2nd Below: Immunohistochemistry of ARC in human skeletal muscle with ARC antibody at 5 µg/ml.

Source : ARC antibody was raised against a peptide corresponding to amino acids 191 to 208 of human origin.

Purification : Affinity chromatography purified via peptide column

Clonality and Clone : This is a polyclonal antibody.

Host : ARC antibody was raised in rabbit.

Immunogen : Human ARC (C-Terminus) Peptide (Cat. No. 2081P)

Tested Application(s) : E, WB, IHC

Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.

Blocking Peptide : Cat. No. 2081P - ARC Peptide

Long-Term Storage : ARC antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Positive Control

• Cat. No. 1201 - HeLa Cell Lysate

Species Reactivity :H

GI Number : 4505419

Accession Number : NP_003937

Short Description : (CT) Apoptosis Repressor with CARD domain

References

1. Koseki T, Inohara N, Chen S, Nunez G. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc Natl Acad Sci U S A 1998;95:5156-60 (RD1299)

For more detail regarding Peptides please visit here : Custom Peptide Synthesis