ARMER Antibody

ARMER Antibody

Catalog# : 3305

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA (1). Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12 (2), other caspases such as caspase-9 are also thought to be activated following ER stress (3). Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Additional Names : ARMER (CT), ARL6IP, AIP1
Description
Left: Western blot ana-lysis of ARMER in mouse small intestine tissue lysates with ARMER antibody at (A) 0।5, (B) 1, and (C) 2 µg/ml. Below: Immunohistochemical staining of human bladder tissue using ARMER antibody at 2 µg/ml.
Source : ARMER antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human ARMER.

Purification : Ion exchange chromatography purified

Clonality and Clone : This is a polyclonal antibody.

Host : ARMER antibody was raised in rabbit.

Immunogen : Human ARMER / ARL6IP / AIP1 (C-Terminus) Peptide (Cat. No. 3305P)

Tested Application(s) : E, WB, IHC

Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.

Blocking Peptide : Cat. No. 3305P - ARMER Peptide

Long-Term Storage : ARMER antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Positive Control

• Cat. No. 1408 - Mouse Small Intestine Tissue Lysate
  

Species Reactivity :H, M

GI Number : 14424435

Accession Number : Q15041

Short Description : (CT) An inhibitor of apoptosis

References

1. Stellar H. Mechanisms and genes of cellular suicide. Science 1995; 267:1445-9.
2. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000; 403:98-103.
3. Lui HM, Chen J, Wang L, et al. ARMER, Apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis. Mol. Cancer Res. 2003; 1:508-18.

For more detail regarding Peptides please visit here : Custom Peptide Synthesis