ARTS Antibody

ARTS Antibody

Catalog# : 3025

Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-b signaling pathway (1). ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene (1-4) is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-b and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.

Additional Names : ARTS
Description
Left: Western blot analysis of ARTS expression in human lung (lane 1), spleen (lane 2), and kidney (lane 3) tissue lysates with ARTS antibody at 2 µg /ml। Below: Immunohistochemistry of ARTS in human lung tissue with ARTS antibody at 2 µg/ml.

Source : ARTS antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human ARTS.

Purification : Affinity chromatography purified via peptide column

Clonality and Clone : This is a polyclonal antibody.

Host : ARTS antibody was raised in rabbit.

Immunogen : Human ARTS Peptide (Cat. No. 3025P)

Tested Application(s) : E, WB, IHC

Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.

Blocking Peptide : Cat. No. 3025P - ARTS Peptide

Long-Term Storage : ARTS antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Positive Control

• Cat. No. 1302 - Human Lung Tissue Lysate
• Cat. No. 1306 - Human Spleen Tissue Lysate
• Cat. No. 1305 - Human Kidney Tissue Lysate
  

Species Reactivity :H

GI Number : 12024871

Accession Number : AAG45673

Short Description : An apoptosis related protein

References

1. Larisch S, Yi Y, Lotan R, Kerner H, et al. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nat Cell Biol 2000;2(12):915-21
2. Depraetere V. The ARTS of apoptosis. Nat Cell Biol. 2000;2(12):E219.
3. Paavola,P., Horelli-Kuitunen,N., Palotie,A. and Peltonen,L. Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene. Genomics 1999;55 (1):122-125
4. Zieger,B., Tran,H., Hainmann, I. , Wunderle,D., Zgaga-Griesz,A., Blaser,S. and Ware,J. Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2. Gene 2000;261(2):197-203

For more detail regarding Peptides please visit here : Custom Peptide Synthesis