The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8) (1). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin (2). Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF) (3). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis (4).
Additional Names : ATR (IN), TEM8
DescriptionLeft: Western blot analysis of ATR in HepG2 cell lysates with ATR antibody (IN) at (A) 0.5, (B) 1, and (C) 2 µg/ml. Below: Immunohistochemical staining of human brain tissue using ATR antibody at 2 µg/ml.
Source : ATR antibody was raised against a peptide corresponding to 13 amino acids near the center of human ATR.
Purification : Ion exchange chromatography purified
Clonality and Clone : This is a polyclonal antibody.
Host : ATR antibody was raised in rabbit.
Immunogen : Human ATR / TEM8 (Intermediate Domain) Peptide (Cat. No. 3117P)
Application : ATR antibody can be used for d
Tested Application(s) : E, WB, IHC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide : Cat. No. 3117P - ATR Peptide
Long-Term Storage : ATR antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1211 - HepG2 Cell Lysate
- Cat. No. 1303 - Human Brain Tissue Lysate
GI Number : 16933551
Accession Number : NP_444262
Short Description : (IN) Anthrax receptor
For more detail regarding Peptide please visit here : Custom Peptide Synthesis
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