Immunogen Conjugates

Immunogen Conjugates

BSI offer pre-miRNA precursor molecules which are single stranded, chemically modified and optimized nucleic acids, which designed to closely mimic endogenous mature microRNA (miRNA) molecules in cells. Our custom defined pre-miRNA precursor molecules provide flexible length and modifications for direct entry into the miRNA processing pathway and are treated identically to endogenous miRNA within cell.

Use of pre-miRNA

With the pre-miRNA, you can control specific miRNA activity, tightly regulate miRNA cellular levels, achieve optimal delivery efficiency with minimal cytotoxicity, miRNA enables up-regulation of miRNA activity for miRNA functional analysis, Since the Pre-miR miRNA Precursor Molecules directly enter the miRNA pathway, they eliminate any non-miRNA cellular response that is seen with siRNA-like designs. Unlike plasmid-based miRNA expression, the Pre-miR miRNA Precursor Molecules are easy to transfect with minimal cellular stress, and are able to be tightly regulated for specific dose response analysis.

All pre-miRNA oligonucleotide offer at BSI

All pre-miRNA oligonucleotide offer at BSI are: Deprotected, desalted and lyophilized, Every oligo is quality checked by MALDI-TOF mass spectrometry, Electrospray ionization mass spectrometry (ESI-MS), capillary electrophoresis (CE), and/or polyacrylamide gel electrophoresis (PAGE), Optional custom QC and preparative services available for in vivo application, Reliable quality and expertise in large-scale synthesis and QSR and cGMP manufacturing is available.