Aldh5A1 Antibody

Aldh5A1 Antibody

Catalog# : 4807

Aldh5A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh5A1 is a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, results in a disorder of the neurotransmitter 4-aminobutyric acid (GABA). Symptoms usually include static encephalopathy, associated with developmental delays, hypotonia, ataxia, speech defects, and seizures. At least two isoforms of Aldh5A1 are known to exist.
Additional Names : Aldh5A1,Aldehyde dehydrogenase family5 member A1, succinate-semialdehyde dehydrogenase, SSDH, SSADH
Description
Left: Western blot analysis of Aldh5A1 in mouse liver lysate with Aldh5A1 antibody at (A) 1 and (B) 2 µg/ml.




Source : Aldh5A1 antibody was raised against a 22 amino acid peptide near the carboxy terminus of the human Aldh5A1.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : Aldh5A1 antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.
Application : Aldh5A1 antibody can be used for detection of Aldh5A1 by Western blot at 1 – 2 µg/ml.
Tested Application(s) : E, WB
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide : Cat.No. 4807P - Aldh5A1 Peptide
Long-Term Storage : Aldh5A1 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
1. Cat. No. 1404 - Mouse Liver Tissue Lysate
Species Reactivity :H, M, R
GI Number : 25777721
Accession Number : NP_733936
Short Description : Aldehyde dehydrogenase family5 member A1
References
1. Vasiliou V and Pappa A. Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. Pharmacology 2000; 61:192-8.
2. Hearl WG and Churchich JE. Interactions between4-aminobutyrate aminotransferase and succinic semialdehyde dehydrogenase, two mitochondrial enzymes. J. Biol. Chem. 1984; 259:11459-63.
3. Gibson KM, Sweetman L, Nyhan WL, et al. Succinic semialdehyde dehydrogenase deficiency: an inborn error of gamma-aminobutyric acid metabolism. Clin. Chim. Acta 1983; 133:33-42.