Thursday, June 2, 2011

AGTR1 Antibody


Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. AGTR1, the type 1 receptor, is thought to mediate the major cardiovascular effects of angiotensin II and may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. AGTR1 has recently been found to regulate the differentiation of bone marrow-derived monocyte lineage progenitors from hematopoietic stem cells, indicating the diversity of the roles of AGTR1.

Additional Names: AGTR1, Angiotensin II receptor type 1, Ang II, AT1, AT1R


Left: Western blot analysis of AGTR1 in mouse kidney tissue lysate with AGTR1 antibody at (A) 1 and (B) 2 µg/ml.

Source:AGTR1 antibody was raised against a 16 amino acid peptide from near the center of human AGTR1.
Purification: Affinity chromatography purified via peptide column
Clonality and Clone: This is a polyclonal antibody.
Host: AGTR1 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application: AGTR1 antibody can be used for detection of AGTR1 by Western blot at 1 - 2 µg/ml.
Tested Application(s): E, WB
Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide:Cat.No. 5391P - AGTR1 Peptide
Long-Term Storage: AGTR1 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control:
1. Cat. No. 1405 - Mouse Kidney Tissue Lysate
Species Reactivity: H, M, R
GI Number: 119599315
Accession Number: EAW78909
Short Description: Angiotensin II receptor type 1
1. Mottl AK, Shoham DA, and North KE. Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: A HuGE review. Gen. in Med. 2008; 10:560-574.
2. Miyazaki Y and Ichikawa I. Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2001; 128:89-97.
3. Tsubakimoto Y, Yamada H, Yokoi H, et al. Bone marrow angiotensin AT1 receptor regulates differentiation of monocyte lineage progenitors from hematopoietic stem cells. Arterioscler. Thromb. Vasc. Biol. 2009; 29:1529-36.

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