Friday, June 17, 2011

DNA Synthesis Primer

For over 20 years, BioSynthesis has provided custom oligonucleotide production services worldwide, including researcher at university, biotechnology and pharmaceutical institutions. We are not only synthesizing standard DNA primer and probes but are also specialized in production and purification of modified oligomers. Base, ribose and backbone modifications and reporter groups like dyes and haptens are routinely incorporated at small discovery research scale to multi-gram ASR/cGMP for clinical diagnostic production. As always, quality is guaranteed!

DNA Synthesis

DNA replication is the process of copying a double-stranded DNA molecule to form two double-stranded molecules. The process of DNA replication is a fundamental process used by all living organisms as it is the basis for biological inheritance. As each DNA strand holds the same genetic information, both strands can serve as templates for the reproduction of the opposite strand. The template strand is preserved in its entirety and the new strand is assembled from nucleotides.

DNA Polymerase

A DNA polymerase is an enzyme that assists in DNA replication. Such enzymes catalyze the polymerization of deoxyribonucleotides alongside a DNA strand, which they "read" and use as a template. The newly-polymerized molecule is complementary to the template strand and identical to the template's partner strand.

Variation Across Species

DNA polymerases have highly-conserved structure, which means that their overall catalytic subunits vary, on a whole, very little from species to species. Conserved structures usually indicate important, irreplicable functions of the cell, the maintenance of which provides evolutionary advantages.

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