Thursday, June 2, 2011

AGTR2 Antibody


Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.

Additional Names: AGTR2, Angiotensin II receptor type 2, AT2, AT2R, MRX88
Left: Western blot analysis of AGTR2 in mouse liver tissue lysate with AGTR2 antibody at 0.5 µg/ml.

Source:AGTR2 antibody was raised against a 16 amino acid peptide from near the center of human AGTR2.
Purification: Affinity chromatography purified via peptide column
Clonality and Clone: Polyclonal
Host: AGTR2 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application: AGTR2 antibody can be used for detection of AGTR2 by Western blot at 0.5 - 1 µg/ml.
Tested Application(s): E, WB
Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide:Cat.No. 5393P - AGTR2 Peptide
Long-Term Storage: AGTR2 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control:
1. Cat. No. 1404 - Mouse Liver Tissue Lysate
Species Reactivity: H, M, R
GI Number: 42766665
Accession Number: AAS45437
Short Description: Angiotensin II receptor type 2
1. Mottl AK, Shoham DA, and North KE. Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: A HuGE review. Gen. in Med. 2008; 10:560-574.
2. Miyazaki Y and Ichikawa I. Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2001; 128:89-97.
3. Laflamme L, Gasparo M, Gallo JM, et al. Angiotensin II induction of neurite outgrowth by AT2 receptors in NG108-15 cells. Effect counteracted by the AT1 receptors. J. Biol. Chem. 1996; 271:22729-35.
4. Stoll M, Steckelings UM, Paul M, et al. The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J. Clin. Invest. 1995; 95:651-7.

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