Saturday, May 21, 2011
DNA To RNA
Bio-Synthesis continued to provide quality DNA to RNA products and services for the research community we provid advanced oligonucleotide tools to accelerate the discovery and application of genomic information. Whether you need d 100 or 100,000 custom oligos for high throughput applications, or multi-gram clinical diagnostic production, our consistency in providing realiable custom DNA, RNA, Constrained Nucleotide, BNA probes and primers and has earned us as an oligonucleotide company of choice!
Research leading to the discovery that RNA can act as a catalyst started in the 1970's. Thomas Cech, at the University of Colorado at Boulder, was studying the excision of introns in a ribosomal RNA gene in Tetrahymena thermophila.
DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as UV light and Radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day
The detection of DNA fragmentation by the use of the TUNEL technique has become a standard technique for the detection of apoptosis in tissue sections. DNA cleavage, detected by the TUNEL technique, is the last irreversible stage of the apoptosis cascade. When the nuclear DNA is cleaved in oligonucleosomal-sized fragments, processes such as transcription are completely abolished.