Friday, May 20, 2011
Antisense oligonucleotides have been used for over twenty-five years in the area of control gene expresion by using a nucleic acid sequence, usually 18-25 bases long (1) , is designed in antisense orientation that will bind to the messenger RNA (mRNA) (2) . In return, it first physical blocking of the translation process by the presence of the short double stranded region, secondly the presence of the RNA-DNA duplex is susceptible to cellular RNase H activity. RNase H cleaves the RNA-DNA duplex region of the mRNA thus preventing the faithful translation of the mRNA (3) .
With more than 24 years acquired expertise in design and synthesis of antisense oligonucleotide has enabled Bio-Synthesis become the leader in providing best antisense design, chemistry for client in the field of basic research, genomic, target validation, therapuetic and drug discovery.
Protein synthesis begins in the cell's nucleus when the gene encoding a protein is copied into RNA. Genes, in the form of DNA, are embedded in in the cell's chromosomes. The process of transferring the gene's DNA into RNA is called transcription. Transcription helps to magnify the amount of DNA by creating many copies of RNA that can act as the template for protein synthesis.
Transcription is the process in which genetic information stored in a strand of DNA is copied into a strand of RNA. The sequence of the four bases in DNA, which are adenine (A), cytosine (C), guanine (G), and thymine (T), is preserved in the sequence of the four bases in RNA, which are A, C, G, and uracil (U).
Molecular basis of heredity. It is a complex giant molecule that contains, in chemically coded form, the information needed for a cell to make proteins. In other words it determines the order in which amino acids are joined to make a specific protein in a cell. DNA is a ladder-like double-stranded nucleic acid, which forms the basis of genetic inheritance in all organisms, except for a few viruses that have only RNA.
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