Friday, May 20, 2011

ELOVL6 Antibody

Catalog# :4571

Lipogenesis is a key event in the energy storage system and is controlled by the transcription factor sterol regulatory element-binding protein (SREBP)-1. Elongation of very long chain fatty acids protein 6 (ELOVL6) is a member of fatty acyl-CoA elongase gene family that converts palmitic to stearic acid and it has been shown to be a target of SREBP-1, playing an important role in de novo synthesis of long-chain saturated and monosaturated fatty acids in conjunction with fatty acid synthase and stearoyl-CoA desaturase ELOVL6 was predicted to be important for tissue fatty acid composition. Recent studies suggest that inhibition of this elongase could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity.

Additional Names : ELOVL6, Elongation of very long chain fatty acids protein 6, hELO2, Fatty acyl-CoA elongase, FACE, Long-chain fatty-acyl elongase, LCE


Western blot analysis of ELOVL6 in Human brain tissue lysate with ELOVL6 antibody at (A) 1 and (B) 2 µg/ml.

Below: Immunohistochemistry of ELOVL6 in human brain with ELOVL6 antibody at 5 µg/ml.

Other Product Images

Source :ELOVL6 antibody was raised against a 16 amino acid peptide near the amino terminus of the human ELOVL6.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : ELOVL6 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application : ELOVL6 antibody can be used for detection of ELOVL6 by Western blot at 1 – 2 µg/ml.
Tested Application(s) : E, WB, IHC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 4571P - ELOVL6 Peptide
Long-Term Storage : ELOVL6 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1. Cat. No. 1303 - Human Brain Tissue Lysate
Species Reactivity : H, M, R
GI Number : 13129088
Accession Number : NP_076995
Short Description : Elongation of very long chain fatty acids protein 6
1. Moon YA, Shah NA, Mohapatra S, et al. Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. J. Biol. Chem. 2001; 276:45358-66.
2. Matsuzaka T, Shimano H, Yahaqi N, et al. Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs. J. Lipid Res. 2002; 43:911-20.
3. Matsuzaka T, Shimano H, Yahaqi N, et al. Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nat. Med. 2007; 13: 1193 -202

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