Wednesday, May 11, 2011

Slitrk1 Antibody


SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette’s Syndrome, it is thought to play only a minor role if at all. This antibody is predicted to have no cross-reactivity to other Slitrk proteins.

Additional Names : Slitrk1 (IN), SLIT and NTRK-like family 1


Left: Western blot analysis of Slitrk1 in human brain tissue lysate with Slitrk1 antibody at (A) 1 and (B) 2 µg/ml.

Below:Immunohistochemistry of Slitrk1 in human brain tissue with Slitrk1 antibody at 2.5 µg/ml.

Other Product Images

Source :
Slitrk1 antibody was raised against a 18 amino acid peptide from near the center of human Slitrk1.
Purification :
Affinity chromatography purified via peptide column
Clonality and Clone :
This is a polyclonal antibody.
Host :
Slitrk1 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application :
Slitrk1 antibody can be used for detection of Slitrk1 by Western blot at 1 – 2 µg/ml.
Tested Application(s) :
Buffer :
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :
Cat.No. 4455P - Slitrk1 Peptide
Long-Term Storage : Slitrk1 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :

1. Cat. No. 1303 - Human Brain Tissue Lysate
Species Reactivity : H, M, R
GI Number : 40217817
Accession Number : NP_443142
Short Description : (IN) SLIT and NTRK-like family 1
  1. Aruga J and Mikoshiba K. Identification and characterization of Slitrk, a novel transmembrane protein family controlling neurite outgrowth. Mol. Cell Neurosci. 2003; 24:117-29.
  2. Aruga J, Yokota N, and Mikoshiba K. Human SLITRK family genes: genomic organization and expression profiling in normal and brain tumor tissue. Gene 2003; 315:87-94.
  3. Abelson JF, Kwan KY, O’Roak BJ, et al. Sequence variants in SLITRK1 are associated with Tourette’s syndrome. Science 2005; 310:317-20.
  4. Fabbrini G, Pasquini M, Aurilia C, et al. A large Italian family with Gilles de la Tourette syndrome: clinical study and analysis of the SLITRK1 gene. Mov. Disord. 2007; 22:2229-34.

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