Childhood and adult obesity in the United States and to a lesser extent the rest of the world has increased dramatically over the past decade. Both environmental and genetic factors are involved in the onset and progression of weight gain. Recently, the potassium channel KCTD15 was identified as a genetic loci associated with higher than normal body mass index (BMI) in humans along with genes such as GNPDA2, MTCH2, FTO, and TMEM18. Further studies on single nucleotide polymorphisms (SNPs) in non-diabetic and diabetic patients showed that FTO was most strongly associated with obesity while MTCH2 and GNPDA2 were still significantly associated with higher than normal BMI levels. At least two isoforms of KCTD15 are known to exist.
Additional Names : KCTD15, Potassium channel tetramerisation domain containing 15
Left: Western blot analysis of KCTD15 in human spleen tissue lysate with KCTD15 antibody at (A) 0.5 and (B) 1 µg/ml.
Below:Immunohistochemistry of KCTD15 in human spleen tissue with KCTD15 antibody at 2.5 µg/ml.
Other Product Images
Source :KCTD15 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human KCTD15.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : KCTD15 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application : KCTD15 antibody can be used for detection of KCTD15 by Western blot at 0.5 – 1 µg/ml.
Tested Application(s) : E, WB, IHC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 5085P - KCTD15 Peptide
Long-Term Storage : KCTD15 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1. Cat. No. 1306 - Human Spleen Tissue Lysate
Species Reactivity : H, M, R
GI Number : 74732704
Accession Number : Q96SI1
Short Description : Potassium channel tetramerisation domain containing 15
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2. Willer CJ, Speliotes EK, Loos RJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genetics 2009; 41:25-34.
3. Renstrom F, Payne F, Nordstrom A, et al. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Human. Mol. Gen. 2009; 18:1489-96.