Monday, May 16, 2011

Slitrk6 Antibody

Catalog# :4479

SLIT and NTRK-like family 6 (Slitrk6) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. Slitrk6 expression has been observed in tissues such as tongue, lung, gastrointestinal tract, and pancreas. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk6 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth. At least two isoforms of Slitrk6 are known to exisit. This antibody is predicted to have no cross-reactivity to other Slitrk proteins.

Additional Names : Slitrk6 (CT), SLIT and NTRK-like family 6


Left:Western blot analysis of Slitrk6 in SK-N-SH cell lysate with Slitrk6 antibody at (A) 0.5 and (B) 1 µg/ml.

Below:Immunohistochemistry of Slitrk6 in human brain tissue with Slitrk6 antibody at 2.5 µg/ml.

Other Product Images

Source :Slitrk6 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Slitrk6.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : Slitrk6 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application : Slitrk6 antibody can be used for detection of Slitrk6 by Western blot at 0. 5 – 1 µg/ml.
Tested Application(s) : E, WB, IHC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 4479P - Slitrk6 Peptide
Long-Term Storage : Slitrk6 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1. Cat. No. 1220 - SK-N-SH Cell Lysate
Species Reactivity : H, M, R
GI Number : 59803110
Accession Number : Q9H5Y7
Short Description : (CT) SLIT and NTRK-like family 6
1. Aruga J and Mikoshiba K. Identification and characterization of Slitrk, a novel transmembrane protein family controlling neurite outgrowth. Mol. Cell Neurosci. 2003; 24:117-29.
2. Aruga J, Yokota N, and Mikoshiba K. Human SLITRK family genes: genomic organization and expression profiling in normal and brain tumor tissue. Gene 2003; 315:87-94.
3. Aruga J. Slitrk6 expression profile in the mouse embryo and its relationship to that of Nlrr3. Gene Expr. Patterns 2003; 3:727-33.

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