Avian Influenza Nonstructural Protein 2 Antibody
Catalog# : 3917
Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however, it is in birds that all subtypes, including the so-called “avian flu” or H5N1, can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. One of the less studied proteins encoded by the influenza virus is the nonstructural protein (NS) 2. NS2 binds to the influenza matrix protein M1 that is bound to the ribonucleoprotein (RNP) complex and mediates the contact between the M1/RNP complex and the cellular exportin CRM, but does not interact with nucleosomes.
Additional Names : Avian Influenza Nonstructural Protein 2, H5N1 NS2, Nonstructural protein 2, nuclear export protein, NEP
Source : Avian Influenza Nonstructural Protein 2 antibody was raised against a synthetic peptide corresponding to 14 amino acids near the middle of the Avian Influenza Nonstructural Protein 2 protein. Efforts were made to use relatively conserved regions of the viral sequence as the antigen.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : Avian Influenza Nonstructural Protein 2 antibody was raised in rabbit. Please use anti-rabbit secondary antibodies.
Application : Avian Influenza Nonstructural Protein 2 antibody can be used for the detection of the Avian Influenza Nonstructural Protein 2 protein from influenza A in ELISA.
Tested Application(s) : E
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide : Cat.No. 3917P - Avian Influenza Nonstructural Protein 2 Peptide
Long-Term Storage : Avian Influenza Nonstructural Protein 2 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity :V
GI Number : 85680916
Accession Number : ABC72654
Short Description : H5N1, M1, exportin, CRM
1. Thompson WW, Shay DK, Weintraub, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003; 289:179-186.
2. Alexander DJ. A review of avian influenza. Proceedings of the European Society for Veterinary Virology (ESVV) Symposium on Influenza Viruses of Wild and Domestic Animals. Vet. Microbiol. 2000; 74:3-13.
3. Neumann G, Hughes MT and Kawaoka Y. Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1. EMBO J. 2000; 19:6751-8.
4. Garcia-Robles I, Akarsu H, Muller CW, et al. Interaction of influenza virus proteins with nucleosomes. Virology 2005; 332:329-36.