Thursday, September 30, 2010

Nucleic Acid Conjugations

Bio-Synthesis offers chemical modifications of nucleic acids at specific sites within individual nucleotides or whithin oligonucleotides which allows various labels to be incorporated into DNA or RNA probes.

Modification process of Nucleic Acids
This modification process can further be use to conjugate with other molecules such as Peptide-oligonucleotide conjugation, Fluorescent oligonucleotide labeling, Non-fluorescent oligonucleotide labeling, Enzyme oligonucleotide conjugation, Oligonucleotide-HRP conjugations etc.

Use of Oligonucleotides
The use of oligonucleotides as therapeutic and diagnostic agents is growing rapidly with many compounds in preclinical and human clinical trials. In many of these applications the oligonucleotide is derivatized or conjugated with another molecular entity. These conjugations are typically performed for the purpose of attaching fluorescent dyes or other diagnostic reporter groups or for attaching compounds that modulate the activity or the pharmacokinetic behavior of the oligonucleotide.

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